SOD2 Knockdown Mouse Model of Early AMD

Mini-Chaperones for Early AMD.

This issue of IOVS presents a novel strategy to develop treatment for nonexudative age-related macular degeneration (dry AMD) that derives from the natural, protective response of RPE cells to cellular stress. Oxidative stress is implicated in AMD pathogenesis and results in the upregulation of small heat shock proteins that act as molecular chaperones to prevent cellular apoptosis and minimize...

Interest of Early Screening for AMD Prevention

Mutated myocilin and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma.

Glaucoma is a multifactorial optic neuropathy characterized by retinal ganglion cell (RGC) death and axonal degeneration leading to irreversible blindness. Mutations in the myocilin (MYOC) gene are the most common genetic factors of primary open-angle glaucoma. To develop a genetic mouse model induced by the synergistic interaction of mutated myocilin and another significant risk factor, oxidat...

SOD2 deficiency promotes aging phenotypes in mouse skin

survival but also pose serious risks to that survival. A particularly striking example was the demonstration in 2003 by the Campisi group that primary mouse fibroblasts have an indefinite proliferative lifespan in 3% oxygen, the amount found in the capillaries feeding the tissues, but greatly shortened ones under normal in vitro culturing conditions, i. e., 20% oxygen [1]. Now, the same group h...

c-fos promotes retinal angiogenesis in a mouse model of neovascular AMD

Program Number: 4987 Poster Board Number: B0193 Presentation Time: 11:00 AM–12:45 PM c-fos promotes retinal angiogenesis in a mouse model of neovascular AMD Ye Sun1, Zhiqiang Lin2, Chi-Hsiu Liu1, Yan Gong1, Raffael Liegl1, Thomas Fredrick1, Steven Meng1, Nicholas Saba1, Samuel Burnim1, Jing Chen1, Lois E. Smith1. 1Department of Ophthalmology, Boston Children’s Hosp/Harvard Med Sch, Boston, MA; ...